Enrique was Isabel’s half-brother, son of Juan II — Isabel’s father — and María of Aragon.
Born on 5 January 1425 in the now-lost Casa de las Aldabas on Calle Teresa Gil in Valladolid; died during the night of 11 to 12 December 1474 in Madrid, possibly by poisoning.
Juana was born on 28 February 1462 in Madrid as Juana of Castile, daughter of Queen Juana of Portugal and King Enrique IV. She died on 12 April 1530 in Lisbon. She was Isabel’s rival in the succession to the throne.
Pacheco (1419–1474), also known as the Marquis of Villena, was one of the most important noblemen at the court of Castile. He grew up alongside Enrique, who would later become King Enrique IV. He later clashed with Enrique, who had begun favoring Beltrán de la Cueva instead.
Juan II de Castilla (1405 – 1454) was the father of Isabel. Died when Isabel was only three years old.
Alfonso el Innocente
Alfonso (1453–1468) was the younger brother of Isabel. He was also known as Alfonso el Innocente (the Innocent). He became king at the age of eleven and died at fourteen.
Alfonso Carillo. bishop of Toledo
Alfonso Carrillo de Acuña (1413–1482). Nephew of Pacheco. He played an important role in the establishment of the marriage between Isabel and Ferdinand.
Juana I, Daughter of Isabel
Juana was born on 6 November 1479, as the third child of Isabel and Fernando, and is known to us as Juana the Mad.
Álvaro de Luna, statesman
Álvaro de Luna was an influential nobleman at the court of King Juan II de Castilla. He died on 2 June 1453 by beheading in the Plaza Mayor of Valladolid.
Cisneros
Francisco Jiménez de Cisneros was a Spanish statesman under the Catholic Monarchs and a cardinal of the Roman Catholic Church.